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	<title>Comments on: PAPER: How reliable are the results from functional magnetic resonance imaging?</title>
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	<link>http://prefrontal.org/blog/2010/02/paper-how-reliable-are-the-results-from-functional-magnetic-resonance-imaging/</link>
	<description>A personal weblog of developmental cognitive neuroscience.</description>
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		<title>By: The brain is a bad metaphor for language &#124; Metaphor Hacker - Hacking Metaphors, Frames and Other Ideas</title>
		<link>http://prefrontal.org/blog/2010/02/paper-how-reliable-are-the-results-from-functional-magnetic-resonance-imaging/comment-page-1/#comment-568</link>
		<dc:creator>The brain is a bad metaphor for language &#124; Metaphor Hacker - Hacking Metaphors, Frames and Other Ideas</dc:creator>
		<pubDate>Wed, 09 Mar 2011 09:48:32 +0000</pubDate>
		<guid isPermaLink="false">http://prefrontal.org/blog/?p=893#comment-568</guid>
		<description>[...] last few years, several reports raised questions about some overreaching by neuroscience (both in methods and assumptions about their validity) but even perfectly good neuroscience can be bad scholarship [...]</description>
		<content:encoded><![CDATA[<p>[...] last few years, several reports raised questions about some overreaching by neuroscience (both in methods and assumptions about their validity) but even perfectly good neuroscience can be bad scholarship [...]</p>
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		<title>By: 【磁核共振】腦部影像研究遭到質疑 &#171; CASE PRESS</title>
		<link>http://prefrontal.org/blog/2010/02/paper-how-reliable-are-the-results-from-functional-magnetic-resonance-imaging/comment-page-1/#comment-387</link>
		<dc:creator>【磁核共振】腦部影像研究遭到質疑 &#171; CASE PRESS</dc:creator>
		<pubDate>Mon, 17 May 2010 06:28:10 +0000</pubDate>
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		<description>[...] CM, Miller MB. (in press). How reliable are the results from functional magnetic resonance imaging? Annals of the New York Academy of [...]</description>
		<content:encoded><![CDATA[<p>[...] CM, Miller MB. (in press). How reliable are the results from functional magnetic resonance imaging? Annals of the New York Academy of [...]</p>
]]></content:encoded>
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		<title>By: Review: Test-Retest Reliability in fMRI &#171; The Amazing World of Psychiatry: A Psychiatry Blog</title>
		<link>http://prefrontal.org/blog/2010/02/paper-how-reliable-are-the-results-from-functional-magnetic-resonance-imaging/comment-page-1/#comment-332</link>
		<dc:creator>Review: Test-Retest Reliability in fMRI &#171; The Amazing World of Psychiatry: A Psychiatry Blog</dc:creator>
		<pubDate>Mon, 08 Mar 2010 23:46:54 +0000</pubDate>
		<guid isPermaLink="false">http://prefrontal.org/blog/?p=893#comment-332</guid>
		<description>[...] freely available here. MindHacks had drawn attention to this article and it is also referenced on Craig Bennett&#8217;s blog. The article, excluding references is just under 10,000 words. Bennett and Miller refer to the Vul [...]</description>
		<content:encoded><![CDATA[<p>[...] freely available here. MindHacks had drawn attention to this article and it is also referenced on Craig Bennett&#8217;s blog. The article, excluding references is just under 10,000 words. Bennett and Miller refer to the Vul [...]</p>
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		<title>By: burak</title>
		<link>http://prefrontal.org/blog/2010/02/paper-how-reliable-are-the-results-from-functional-magnetic-resonance-imaging/comment-page-1/#comment-329</link>
		<dc:creator>burak</dc:creator>
		<pubDate>Sun, 07 Mar 2010 12:08:58 +0000</pubDate>
		<guid isPermaLink="false">http://prefrontal.org/blog/?p=893#comment-329</guid>
		<description>Thank you very much for this great paper,

The paper presents different measures of measuring reliability and which one is better than the other.
But it made me think about one particular question which is asking how much reliability we should expect when we scan the
subject again in the next couple weeks or so. Here if we expect high reliability we are excepting (prior hypothesis) that every time we do a certain task in different occasion we are in same mental state. Therefore, we are eliminating the effect of familiarity and novelty when we experience similar situations. I want to draw attention to this, this can not explained by internal physiological noise, if the underlying neural processes are dependent on internal states (mood, feeling, novelty and so on). Nowadays researchers use mock fMRI trials in fake scanners to decrease the level of anxiety. Furthermore, if the general computation mechanisms underlying our neural machinery is high dependent on the novelty as  Karl Friston suggested by his unified theory of brain (free energy) model, how much does novelty effects the retest reliability is I think needs a new  mathematical model not present in the paper.

&lt;em&gt;I am very glad you liked the paper.  You bring up a lot of valid points in your comment.  As you state, we must acknowledge that no two measurements will every be precisely the same.  This variability can come from a wide variety of sources, including task learning, stimulus novelty, and changes in baseline mental state.  We can try to control for many of these factors, but certainly not all.  New studies to investigate the influence of these factors are necessary, as are new approaches to the quantification of reliability.  ~ Craig [Prefrontal]&lt;/em&gt;</description>
		<content:encoded><![CDATA[<p>Thank you very much for this great paper,</p>
<p>The paper presents different measures of measuring reliability and which one is better than the other.<br />
But it made me think about one particular question which is asking how much reliability we should expect when we scan the<br />
subject again in the next couple weeks or so. Here if we expect high reliability we are excepting (prior hypothesis) that every time we do a certain task in different occasion we are in same mental state. Therefore, we are eliminating the effect of familiarity and novelty when we experience similar situations. I want to draw attention to this, this can not explained by internal physiological noise, if the underlying neural processes are dependent on internal states (mood, feeling, novelty and so on). Nowadays researchers use mock fMRI trials in fake scanners to decrease the level of anxiety. Furthermore, if the general computation mechanisms underlying our neural machinery is high dependent on the novelty as  Karl Friston suggested by his unified theory of brain (free energy) model, how much does novelty effects the retest reliability is I think needs a new  mathematical model not present in the paper.</p>
<p><em>I am very glad you liked the paper.  You bring up a lot of valid points in your comment.  As you state, we must acknowledge that no two measurements will every be precisely the same.  This variability can come from a wide variety of sources, including task learning, stimulus novelty, and changes in baseline mental state.  We can try to control for many of these factors, but certainly not all.  New studies to investigate the influence of these factors are necessary, as are new approaches to the quantification of reliability.  ~ Craig [Prefrontal]</em></p>
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		<title>By: Some links #3 &#171; A Replicated Typo</title>
		<link>http://prefrontal.org/blog/2010/02/paper-how-reliable-are-the-results-from-functional-magnetic-resonance-imaging/comment-page-1/#comment-328</link>
		<dc:creator>Some links #3 &#171; A Replicated Typo</dc:creator>
		<pubDate>Sat, 06 Mar 2010 21:46:01 +0000</pubDate>
		<guid isPermaLink="false">http://prefrontal.org/blog/?p=893#comment-328</guid>
		<description>[...] are fMRI results? Another question I&#8217;m not so sure about. However, Prefrontal.org has a full paper on providing something of an answer. The key sentence: &#8220;the results from fMRI research may be [...]</description>
		<content:encoded><![CDATA[<p>[...] are fMRI results? Another question I&#8217;m not so sure about. However, Prefrontal.org has a full paper on providing something of an answer. The key sentence: &#8220;the results from fMRI research may be [...]</p>
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